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“索坦”治療胃腸道間質瘤 患者須知
- 來源： 百濟藥房藥訊 作者：百濟動態 發佈時間：2008-3-18 16:15:00
sutent is a medicine that treats cancer. It comes in 12.5-mg, 25-mg, and 50-mg capsules. You take SUTENT once per day by mouth. Do not open the capsules.
SUTENT has been approved by the FDA to treat patients with gastrointestinal stromal tumor (GIST). SUTENT is used when the medicine Gleevec® (imatinib mesylate) does not stop the cancer from growing or when you cannot take Gleevec.
索坦已經被FDA批准用於治療胃腸道間質瘤（GIST）患者，適用於使用格列 （甲磺酸伊馬替尼）無效、進展或不能使用格列衛的患者。
SUTENT is available by prescription only. Your doctor has prescribed SUTENT because he or she believes it is the most appropriate treatment for you. SUTENT may not be appropriate for all GIST patients and has not been studied in children. For many patients, SUTENT may slow or stop the growth of cancer and may help to shrink tumors. SUTENT may not work the same in every person.
SUTENT is available by prescription only. Your doctor has prescribed SUTENT because he or she believes it is the most appropriate treatment for you. SUTENT may not be appropriate for all GIST patients and has not been studied in children. For many patients, SUTENT may slow or stop the growth of cancer and may help to shrink tumors. SUTENT may not work the same in every person.
索坦隻能透過醫生處方獲得。醫生給您開索坦是因為他/她認為這是對您最好的治療方法。索坦並不適合所有的胃腸道間質瘤的患者，且並未對兒童患者進行研究。對很多患者，索坦可以延緩或阻止腫瘤的進展，並幫助消退腫瘤。但索坦對每個人的作用不一樣。
索坦的作用機理？
SUTENT may slow or stop some cancers, such as GIST. It works by blocking 2 basic processes that cause tumors to grow and spread. These processes are called proliferation and angiogenesis.
索坦可以延緩或阻止某些腫瘤的進展，如胃腸道間質瘤。它透過阻滯被稱為腫瘤繁殖和血管生成的兩個過程（引起腫瘤的生長和擴散）來發揮作用。
proliferation繁殖
This is when a cell divides, creating 2 cells where there used to be only 1. Like the other cells in your body, cancer cells divide. The difference is that cancer cells divide more times than they should, forming a tumor. SUTENT may help slow down this process.
這個過程指的是一個細胞一分為二，變成兩個細胞。像正常細胞一樣，癌細胞也是透過這種分裂的方式進行繁殖。它們的區別在於癌細胞比普通細胞分裂速度要快得多，從而形成腫瘤。索坦可以幫助延緩這個過程。
Angiogenesis 血管生成
Angiogenesis 血管生成
This is when new blood vessels form. These new blood vessels give tumors the nutrients and oxygen they need to grow. SUTENT may help stop this process.
這個過程指的是新血管的形成。新形成的血管提供腫瘤生長所需的營養和氧分。索坦可以阻止這個過程。
SUTENT may help stop proliferation and angiogenesis by blocking the signals that cause them. Without these 2 processes, tumors cannot grow.
SUTENT may help stop proliferation and angiogenesis by blocking the signals that cause them. Without these 2 processes, tumors cannot grow.
索坦可以透過阻止細胞信號傳導來阻止腫瘤細胞的繁殖和腫瘤血管的形成。沒有這兩個過程，腫瘤就不能生長。
怎樣和醫生溝通？需要告訴醫生什麼？
Before starting treatment, tell your doctor if you are pregnant, could be pregnant, or plan to get pregnant. SUTENT may harm an unborn baby.
開始治療前，如果您已經懷孕、可能懷孕或計劃懷孕，請告訴醫生。索坦可以對胎兒造成傷害。
Tell your doctor if you are breastfeeding. Do not breastfeed while you are being treated with SUTENT.
如果您正在母乳餵養，請告訴醫生。使用索坦進行治療期間務必不要進行母乳餵養。
Tell your doctor about all of your medical conditions, especially if you have any of the following:
- Heart problems
- High blood pressure
- Kidney function problems (other than cancer)
- Liver problems
- Any bleeding problems
- Seizures
告訴您的醫生關於您的疾病狀況的所有資訊，尤其當您有以下任何情況時：心臟問題、高血壓、腎功能不全（除了癌症）、肝臟問題、任何齣血問題和癲癇。
Tell your doctor about all of the medicines you take, including prescription drugs, over-the-counter drugs, vitamins, and herbal products. Some medicines can react with SUTENT and cause serious side effects, including St. John's Wort. Do not take St. John's Wort while taking SUTENT.
告訴您的醫生您的正在進行的用藥情況，包括處方藥、OTC、維他命和草藥。一些藥品可以和索坦相互作用而引起副作用，包括貫葉連翹提取物。
Other medicines can react with SUTENT. These include:
· Dexamethasone (a steroid)
· Medicine for:
· Tuberculosis (TB)
· Infections (antibiotics)
· Depression
· Seizures (epilepsy)
· Fungal infections (antifungals)
· HIV (AIDS)
其他能與索坦相互作用的藥品包括:地塞米松、治療結核的藥物、抗生素、抗抑鬱劑、抗癲癇、抗真菌類藥物和抗艾滋病藥物。
Keep a list of your medicines and show it to your doctor or pharmacist. Also, talk with your doctor before starting any new medicines.
把您所用的藥品做一個清單交給您的醫生或藥師。同時，在開始服用新藥前先諮詢下醫生。
怎樣服用索坦？
|
SUTENT comes in 12.5-mg, 25-mg, and 50-mg capsules that are taken once per day by mouth. Most patients take SUTENT on a dosing cycle: they take SUTENT every day for 4 weeks (28 days), then stop for 2 weeks (14 days). Patients repeat this cycle for as long as their doctor tells them to. |
索坦是一種膠囊製劑，有12.5毫克、25毫克和50毫克三種不同的規格。患者需按療程服用直到醫生通知停藥：口服，每天一次，一個療程6周，頭四周每天一次頓服50毫克，然後停藥並觀察兩周。
Important things to remember
Important things to remember
用藥須知
Follow your doctor's or nurse's instructions on how and when to take SUTENT
怎樣服用和何時服用索坦請遵照醫生和護士的指導。
Make sure to tell your doctor or nurse if you are taking any other medicines, vitamins, or herbal products
如果您正在服用維他命、草藥或其他藥品，請務必告訴您的醫生。
This includes any supplements or over-the-counter products
Take SUTENT exactly the way your doctor tells you to. Do not open the capsules
Try to take SUTENT at about the same time each day
SUTENT can be taken with or without food
Do not drink grapefruit juice or eat grapefruit because this can change the amount of SUTENT in your body
Do not take St. John's Wort while taking SUTENT
If you miss a dose, take it as soon as you remember unless it is close to the time for your next dose. Do not take more than 1 dose of SUTENT at a time, and tell your doctor or nurse if you miss a dose
Call your doctor right away if you take too much SUTENT (more than 1 dose of SUTENT at a time)
這些產品包括，任何補品、OTC產品。
請按照醫生告訴您的方法正確服用，一定不要嚼開膠囊。
每天儘量在固定時間服藥。
可以和或不和食物一起使用。
一定不要吃葡萄或飲用葡萄汁，因為葡萄所含的物質可以改變您體內的索坦的濃度。
如果忘記服藥，當您記起時請立即服用，除非已經到貨就要到下一次服藥的時間了。一次不能服用過量，忘記服藥請通知您的醫生和護士。
服用過量請立即通知您的醫生（超過一次該服用的劑量）
相關病種藥品： 胃腸道間質瘤 腎癌
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中華人民共和國電信與資訊服務業務備案證書號：粵ICP備05009979號
互聯網藥品資訊服務資格證書編號:(粵)-非經營性-2006-0023
藥品經營許可證 藥品經營質量管理規範認證證書 消費者滿意商店 廣州市藥品經營誠信企業
本公司常年法律顧問： 廣東金輪律師事務所
本公司及客戶合法權益均受法律保護， 任何侵犯本公司及客戶利益的單位和個人必將受到法律追究。
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